Research Progress in the Biosynthesis of Amino Acids from Non-grain Feedstocks

Abstract:

Biomanufacturing is the primary method for amino acid production. However, conventional fermentation is limited to grain feedstocks, facing long-standing bottlenecks such as competition with the food supply and high costs. Therefore, developing novel green conversion systems based on non-grain feedstocks, such as agricultural waste and industrial by-products, is of great significance. This approach not only mitigates the industry’s reliance on limited grain resources but also facilitates the achievement of dual carbon goals. The research progress in amino acid synthesis from non-grain feedstocks, including cane molasses, lignocellulose, glycerol, and acetate, was summarized. Furthermore, the critical issues in bioconversion were identified, and the engineering strategies to overcome these obstacles were discussed to facilitate the construction of next-generation amino acid cell factories.