Effects of Ligilactobacillus salivarius CCFM1398 and Its Postbiotics on Orthodontic-induced Bone Resorption in Rats

Abstract:

[Objective]This study aims to evaluate the alleviating effects of Ligilactobacillus salivarius (L. salivarius)CCFM1398 and its postbiotics on orthodontic-induced bone resorption in rats.[Method]This study used MC3T3-E1 osteoblast model and the rat model of orthodontic-induced bone resorption to comprehensively evaluate the biological activity of L. salivarius CCFM1398 and its postbiotics in modulating alveolar bone resorption.[Result]L. salivarius CCFM1398 significantly induced the expression of osteoprotegerin (OPG) in MC3T3-E1 cells. This strain or its postbiotics significantly reduced the probing depth and gingival index score of the rat model of orthodontic-induced bone resorption. They ameliorated bone resorption by reducing the number of osteoclasts and relieved gingival inflammation by down-regulating the expression levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and myeloperoxidase (MPO).[Conclusion]L. salivarius CCFM1398 and its postbiotics can ameliorate orthodontic-induced bone resorption in rats. The findings provide a theoretical basis for the development of probiotic/postbiotic agents with bone resorption-modulating functions.