Research Progress in the Regulation of Intestinal Stem Cell Homeostasis by Dietary Patterns

Abstract:

Intestinal stem cells (ISCs) located at the bottom of intestinal crypts are the key factors driving the repair and rapid renewal of the intestinal epithelium. Their proliferation and differentiation are finely regulated by the microenvironment of the niche. ISCs, as dietary nutrient sensors, can respond to different dietary signals to regulate intestinal homeostasis. The author systematically summarizes the main signaling pathways involved in the regulation of ISCs and reviews the effects and functioning mechanisms of dietary patterns such as high-fat diets, intermittent fasting, calorie restriction, and ketogenic diets on the homeostasis of ISCs, aiming to provide a theoretical basis for the development and application of dietary intervention strategies targeting ISCs in maintaining intestinal health and overall homeostasis.