Abstract:Objective This study aims to investigate the effect of the Ginkgo biloba leaf extract (GBE) and water-soluble tomato concentrate (WSTC) complex on hyperlipidemia (HLP) rats.Method From 40 SD rats, 10 rats were selected as blank control (CON) group, and the remaining 30 rats were modeled for HLP and then randomly allocated into model control (MOD), positive control (PC), and GBE+WSTC complex groups. After 45 d of administration, serum samples were collected for the measurement of the levels of lipid indicators: concentrations of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C); mechanism indicators were determined: mass concentrations of low-density lipoprotein receptor (LDLR), hydroxy-3-methyl glutaryl coenzyme A reductase (HMG-CoAR), and cholesterol 7-hydroxylase (CYP7A1); antioxidant indicators were assayed: levels of malondialdehyde (MDA), total superoxide dismutase (T-SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px).Result Compared with the MOD group, the GBE+WSTC complex group showed highly significant reducations in the concentrations of TC and LDL-C in the serum (P<0.01), and an extremely significant decrease in the concentration of TG (P<0.001), while there was no significant difference in the concentration of HDL-C (P>0.05). Among the mechanism indicators, the mass concentration of LDLR was significantly increased (P<0.05), while the mass concentration of HMG-CoA was significantly decreased (P<0.05) in the GBE+WSTC complex group in comparison with the MOD group. Particularly, the mass concentration of CYP7A1 showed an extremely significant increase (P<0.001). In terms of antioxidant indicators, the GBE+WSTC complex group showed an extremely significant declined concentration of MDA (P<0.001), an extremely significant enhanced activity of SOD (P<0.001), and no significant difference in GSH and GSH-Px (P>0.05).Conclusion The GBE+WSTC complex can effectively alleviate the symptoms of HLP in rats. The findings provide a theoretical basis for the study of the blood lipid-lowering function.
