Abstract:Various dietary factors, including probiotics, vitamin D, and inositol, have been shown to alleviate gestational diabetes mellitus (GDM). However, research on the combined intervention of these dietary factors for GDM remains limited. The author aimed to combine these dietary factors and modulate various metabolic pathways to address the complex metabolic disturbances associated with GDM. A GDM mouse model was induced by streptozotocin (STZ) combined with a high-fat diet. The dosage was 5×108 CFU/d for probiotics, 5 μg/(kg·d) for vitamin D, and 100 mg/(kg·d) for inositol. The results indicated that, compared to individual probiotic interventions or pairwise combinations, the three-component dietary intervention more effectively regulated the gut microbiome, alleviated inflammation, oxidative stress, endoplasmic reticulum stress, and disturbances in hepatic glucose and lipid metabolism, as well as pancreatic damage, and improved glucose and insulin homeostasis. This supports the hypothesis that the synergistic effects of these three dietary factors, through their joint regulation of multiple metabolic pathways, can lead to improved health outcomes and greater economic benefits.
