Abstract:Gut microbiota plays a crucial role in host health and is closely related to bone metabolism disorders during aging. The author aimed to investigate the effects of Bama Ampelopsis Grossedentata (AG), known for its longevity properties, on bone metabolism in aging mice, to assess the potential of AG polyphenols to improve gut microbiota composition in aging mice. The results showed that polyphenols could up-regulate the levels of superoxide dismutase, glutathione, and total antioxidant power, while down-regulate the content of malondialdehyde in the liver of mice. Simultaneously, AG polyphenols could promote bone formation and reduce bone resorption by improving the bone metabolism in aging mice, up-regulating the expression of Osterix gene, and reducing the expression of Acp5. Furthermore, AG polyphenols could modulate the gut microbiota composition in aging mice and promote the production of acetic acid, propionic acid, and butyric acid in feces. In conclusion, AG polyphenols have potential as a future prebiotic to mitigate age-related bone loss and regulate gut microbiota, thereby achieving the goal of delaying aging.
