Protective Effect of Selenium-Enriched Peptide of Cardamine violifolia on Alcohol-Induced Oxidative Stress Damage in the Liver of Mice

Abstract:

[Objective] This study aimed to investigate the protective effect of selenium-enriched peptide of Cardamine violifolia (SPE) on the alcohol-induced oxidative stress damage in the liver of mice. [Method] A mouse model of alcoholic liver damage was established by gradient alcohol gavage. The effects of SPE on the serum levels of biochemical indicators, liver oxidative stress indicators, liver histopathology and liver metabolic profile in mice were studied. [Result] SPE significantly alleviated alcohol-induced liver damage and elevated the levels of antioxidant enzymes in the liver. Metabolomics results showed that SPE significantly recovered the levels of 37 metabolites in the liver of mice. These metabolites were involved in metabolic pathways such as biosynthesis of unsaturated fatty acids, linoleic acid metabolism, and glycerophospholipid metabolism. [Conclusion] SPE exerts a positive protective effect on alcohol-induced oxidative stress injury in mouse liver by regulating the activation of linoleic acid metabolism, biosynthesis of unsaturated fatty acids, and glycerophospholipid metabolism.