Abstract:Benzo[a]pyrene (B[a]P), as a polycyclic aromatic hydrocarbon (PAHs) with the highest toxicity and a potent carcinogen, widely exists in the high-temperature processed food. A large number of epidemiological studies have shown that B[a]P is closely related to the occurrence and development of many diseases. MicroRNA (miRNA) is a short (17-25 nucleotides) non-coding RNA, which negatively regulates specific target genes through mRNA degradation or translation inhibition. MiRNA plays an important role in the process of B[a]P-induced carcinogenicity, reproductive toxicity, neurotoxicity, and other processes. Based on the existing findings, this study reviews the mechanism of miRNA in the toxicity process induced by B[a]P, aiming to further reveal the toxicological mechanism of B[a]P and to provide new research directions and ideas for the disease prevention and food safety control.
