Abstract:The effects of deep-frying edible oil (DFEO) on liver injury in rats and its mechanism were studied using oralgavage of DFEO with given doses. After 6 weeks of intervention, liver index in the DFEO group decreased significantly(P<0.05), while the serum levels of aspartate transaminase(ALT) and aspartate aminotrans ferase(AST) significantly increased (P<0.01).Meanwhile, observation of tissue sections of liver showed that a large number of fat vacuoles and liver sinusoidal expansion in the DFEO group. However, liver cell boundaries were not clear and inflammatory cell infiltration appearedin local glands. The quantitative real-time PCR results showed that 6 weeks continuous consumption of DFEO would cause significant down-regulation of Gsta2、Gsta3、Gclc、Gclm in rat liver tissues(P<0.01). DFEO will cause serious damage to the liver tissue and destroyliver cell morphology, and its long-term intake will damage the normal gene expression leading tonormal life activities affection.
