Study on the Anti-Diabetic Effects of Paecilomyces hepiali

Abstract:

In type 1 diabetes mellitus rat model induced by STZ，the effects of Paecilomyces hepialid mycelium on hypoglycemic，antioxidation and glucose metabolism are investigated systemtically. Paecilomyces hepiali mycelium can effectively increase the levels of weight and reduce blood glucose in diabetes rat after 4-week administration. Biochemical indicators results show that Paecilomyces hepiali mycelium significantly enhanced the contents of insulin，promoted glucose absorption，accelerated glucose metabolism and inhibited glycosylated hemoglobin synthesis in serum. Paecilomyces hepiali mycelium improvs antioxidant activity through enhancing the levels of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px）. Furthermore，Paecilomyces hepiali mycelium increases the glycogen synthesis of liver and muscle and inhibited the degradation of glycogen. Pathological sections of kidney and pancreas in rats show that Paecilomyces hepiali mycelium improves the pathological changes of diabetic nephropathy indicating its therapeutic effect. Collectively，Paecilomyces hepiali mycelium has significant hypoglycemic activity，and its activity may be achieved by increasing the body's glucose metabolism and antioxidant activity.