Protective Activities of Soyasaponin I，II and Soyasapogenol B Against Aflatoxin B1 and Benzo[a] Pyrene-Induced Mutagenicity

Abstract:

Inhibitory activities of soyasaponin I，II and their aglycone for aflatoxin B1（AFB1） and benzo[a]pyrene（B[a]P）-induced mutagenicity were investigated. In the Ames assay，Salmonella typhimurium strains TA98 and TA100 were selected for frameshift and base substitution mutations，respectively. Three compounds showed remarkable protection against AFB1 and B[a]P-induced mutations，with the exception that at the low concentration of 0.3 mg/plate soyasaponins I and II did not significantly inhibit the frameshift mutation. Three compounds also effectively protected against the formation of AFB1-DNA adduct in HepG2 cells and B[a]P-DNA adduct in BEAS-2B cells，with