Intestinal Absorption of Curcumin Solid Lipid Nanoparticles in Rats

Abstract:

To prepare the curcumin solid lipid nanoparticles（CNSLN） with emulsion-ultrasonic and compare the intestinal absorption of free curcumin（CRM） and CNSLN. Single-pass intestinal perfusion（SPIP） model was used to study the intestinal absorption and Ultraviolet spectrometric assay was used to determine the content of CRM. The CNSLN presented as small round or oval under transmission electron microscope（TEM） with the diameter of about（120.7±5.4） nm，zeta potential was（-41.90±1.81） mV，average entrapment efficiency was（91.12±0.42） %. The absorption rate constant（Ka），effective permeability（Peff），percent absorption rate W（%） of CRM and CNSLN in duodenum，jejunum，ileum and colon both were significant difference（P<0.01），and CNSLN was more than 2 times as much as CRM. The maximum segments of CNSLN absorption was colon. The results indicated that the absorption of CNSLN in rats is better than CRM，and CNSLN could obviously enhance the absorption of CRM in rats.