Pharmacokinetics and Bioequiavailability of Intravenous Uricase Self-Assembly Hollow Nanospheres

Abstract:

To study the pharmacokinetic and bioequivalence of hollow nanospheres self-assembled by hyaluronic acid-graft-poly（ethylene glycol）（HA-g-PEG） and sulfobutyl ether-beta-cyclodextrin（SCD） containing uricase（UHPSD） in SD rats. Rats were administrated with（i.v.） UHPSD and UOX，respectively. Blood sample were collected from eye socket，and the activity of uricase were assayed. Compartmental pharmacokinetics were analyzed by DAS 2.1.1 software，then the bioequivalence was judged. The activity-time curve of UHPSD and UOX were conformed to a two-compartment model with a lag time.