Early Warning of Influenza Virus HA Protein Sequences

Abstract:

This article constructed the algorithm of mutation degree by comparing the difference of two consecutive year's reports on HA protein sequences of pandemic influenza virus. Based on 1916～2014 HA protein sequences，the mutations of every year were calculated by the algorithm，and thus it was observed that the mutation values of four major flu outbreak years were higher than those of the adjacent years，and the higher of the mutation value，the greater the scope and impact of pandemic influenza. This approach was rational and would benefit the study of influenza outbreak as well as the early warning and defense.