Preparation and Characteristics Study of the pH-Responsive Hyaluronic Acid-Gossypol Nanoparticles

Abstract:

A pH-responsive hyaluronic acid-gossypol conjugate was prepared based on boronate ester，which could be used as prostate cancer therapy. The conjugate could self-assemble into nanoparticle which morphology was observed by transmission electron microscopy. The nanoparticles were well-dispersed with 40 nm diameter. The pH responsible drug release behavior was confirmed by in vitro drug release study. In vitro cytotoxicity study illustrated a favorable selectivity，since the half maximal inhibitory concentration（IC50） of the nanopaticles against prostate cancer cells was lower than that of normal cells.The designed nanoparticle showed great potential for targeted delivery of gossypol and treatment of prostate cancer.