Research Progress of Aptamer for Small Molecule Target

Abstract:

Aptamer as a single-stranded oligonucleotide can bind to target with high affinity and selectivity. Although many viable approaches for biosensing，diagnostics，and therapeutics have emerged，relatively few aptamers binding to small molecules exist. Small molecules are very important targets with diverse biological functions and clinical and co mMercial uses. Therefore，developing novel and effective molecular recognition probes for these compounds are greatly interesting. This paper will highlight various challenges during aptamer development relative to small molecule targets，as well as opportunities for their application in biosensing and food safety.