Construction of Supramolecular Hydrogel with Dual-Function Anti-Inflammation Activities: Morphology, Properties and Performance

Abstract:

A supramolecular hydrogel with dual function of anti-inflammation activities was prepared from chitosan-β-cyclodextrin and dextranmodified with a nonsteroidal anti-inflammatory drug (ibuprofen) self-assembled via a guest-host inclusion interaction. The hydrogel with uniform porous structure was observed under scanning electron microscope. Ibuprofen could be quickly released with esterase added and stays stable without esterase. In addition, the hydrogel has great potential of clinical application in wound healing since it possesses efficient anti-microbial and anti-inflammation activities.