Pigment Production by Fermentation of Fusarium(Fusarium sp. JN158) and It's Anti-Cancer Activity

Abstract:

Through the separation and structural analysis of the pigment produced by Fusarium fermentation,the research aims to screen the anti-tumor active components. Fusarium was identified by using morphological and molecular biology methods. The pigmen was isolated by HPLC,the production structure was identified by UV,IR,NMR.,and the screening of anti-tumor activity was by MTT. The results showed that the pigment from Fusarium produced a total of six different peaks,the molecular weight is about 380,the VI peak,which is the anthocyanins,can inhibit the A539,MCF-7,MKN-45,HepG2,SW620 five different tumor cell proliferation in a concentration- dependent manner,among them MCF-7 breast cancer cells were inhibited most (P<0.01),so the VI compound with a new structure from Fusarium sp JN 158,may be a good treatment for breast cancer.