Simultaneous Determination the Migration of 4,4’-Bis(Dimethylamine) Benzophenone, 4-(Dimethy Lamino) Benzophenone and 2-Isopropythioxanthone from Paper Package by Magnate Solid Phase Extraction-High Performance Liquid Chromatography-Tandem Mass Spectrometr

Abstract:

In this manuscript,a magnate solid phase extraction-high performance liquid chromatography-tandem mass spectrometry(MSPE-HPLC-MS/MS) method was established to determine the migration of 4,4’-Bis(dimethylamine) benzophenone,4-(Dimethy lamino) benzophenone,2-Isopropythioxanthone from paper package.The analytes was separated on an Agilent Eclipse AAA C18 column with a mobile phase of methanol-water in gradient elution mode at the flow rate of 0.5 mL/min,the mass spectrometry worked in positive ion mode.Moreover,the extraction parameters which affect efficiency were optimized and the results demonstrated that a good linearity in the concentration range of 0.5 ～50.0 ng/mL for 3 analytes.The correlation coefficients were all higher than 0.999.Average recoveries of 3 analytes at three spiked level ranged from 78.3 to 92.1 %,with RSDs less than 7.4 %.The limits of quantification and detection of the method was 0.5 and 0.2 ng/mL,respectively.The method was proven to be sensitive and simple,and was suitable for the rapid determination the real migration of 4,4’-Bis(dimethylamine) benzophenone,4-(Dimethy lamino) benzophenone,2-Isopropythioxanthone from paper package.