Abstract:The objective of this study is to investigate the protective effect of purple sweet potato on liver injury mice which caused by CCl4 and BCG+LPS.For this,a total of 100 male ICR mice were randomized divided into 2 big groups according to the injury methods and then equally randomized into 5 small groups: normal control group,bifendate control group,liver injury control group,low and high dose of purple sweet potato group.Those mice feeding them with corresponded feedstuff.Observed ALT,AST level in the blood and MDA,GSH level in the liver after 12 hours treatment,then calculated the liver and spleen index in the mice.Results: The liver,spleen index,alanine aminotransferase(ALT),aspartate aminotransferase(AST) level in the blood and malondialdehyde(MDA),glutathione(GSH) level in the liver of mice in the treat control groups were significantly different from that in the liver injury control group(P<0.05),and the liver,spleen index level are significantly correlated with ALT,AST in the blood and MDA,GSH in the liver(P<0.05).Conclusion The purple sweet potato exhibited a significant regulated effect on both CCl4 and BCG+LPS induced the liver injury in mice,.The mechanism may be related to reducing enzyme,the level of lipid peroxidation,and preventing liver cell necrosis.
