饮食模式调控肠道干细胞稳态的研究进展

Research Progress in the Regulation of Intestinal Stem Cell Homeostasis by Dietary Patterns

摘要:

位于肠隐窝底部的肠道干细胞（intestinal stem cells，ISCs）是驱动肠上皮修复与快速更新的关键因素，其增殖和分化功能受生态位微环境的精细调控。ISCs作为膳食营养的感受器，可通过响应不同饮食信号调节肠道稳态。作者总结了调控ISCs的主要信号通路，综述了高脂饮食、间歇性禁食、热量限制及生酮饮食等饮食模式对ISCs稳态的影响和作用机制，旨在为靶向ISCs的膳食干预策略的开发及其维持肠道健康和机体稳态中的应用提供理论依据。

Abstract:

Intestinal stem cells (ISCs) located at the bottom of intestinal crypts are the key factors driving the repair and rapid renewal of the intestinal epithelium. Their proliferation and differentiation are finely regulated by the microenvironment of the niche. ISCs, as dietary nutrient sensors, can respond to different dietary signals to regulate intestinal homeostasis. The author systematically summarizes the main signaling pathways involved in the regulation of ISCs and reviews the effects and functioning mechanisms of dietary patterns such as high-fat diets, intermittent fasting, calorie restriction, and ketogenic diets on the homeostasis of ISCs, aiming to provide a theoretical basis for the development and application of dietary intervention strategies targeting ISCs in maintaining intestinal health and overall homeostasis.