基于Aβ学说的抗阿尔茨海默病药物研究进展

Development of Anti-Alzheimer’s Disease Drugs Based on Aβ Hypothesis

摘要:

阿尔茨海默病（Alzheimer’s disease，AD）是一种进行性神经退行性疾病，其广泛流行已经成为不容回避的社会公共健康问题，因此开发安全有效的抗AD药物迫在眉睫。目前基于“淀粉样蛋白（Aβ）学说”开发的药物占主流地位，作者从减少Aβ产生、增加Aβ清除、抑制Aβ与神经元结合和抑制Aβ聚集等4个方面简要综述了目前进入临床的基于Aβ学说开发的抗AD药物的研究进展，为进一步研发抗AD药物提供理论依据。

Abstract:

Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is considered as one of the most intractable medical problems with heavy social and economic burden. Currently, the therapeutic strategies development based on Aβ hypothesis is a research hotspot. The research progress on therapeutic strategies developed based on the mechanism of reducing Aβ synthesis, increasing Aβ degradation, blocking the interaction of Aβ and neurons, and inhibiting Aβ aggregation are reviewed to provide basis for the further development of anti-AD drugs.