群体感应调控下的乳酸菌细菌素合成

Bacteriocin Synthesis of Lactic Acid Bacteria under Quorum Sensing

摘要:

细菌素是一种在新陈代谢过程中由核糖体合成的具有抑菌作用的抗菌肽，因此被作为天然、无毒抗菌剂并广泛应用到食品行业中。群体感应是细菌细胞间通过对自诱导物浓度的感知，从而对基因表达进行调控的行为，现已证明乳酸菌的群体感应是细菌素合成的关键调控机制。作者主要综述了目前乳酸菌细菌素的研究现状、细菌素的系统分类、群体感应信号的转导机制及其对乳酸菌细菌素合成的调节，以促进对细菌素的研究及应用。

Abstract:

Bacteriocin is a kind of antibacterial peptide synthesized by ribosomes during the metabolism process, which is widely used in the food industry as a natural and non-toxic antibacterial agent. Quorum sensing is an act of regulating the genes expression by response to the concentration of autoinducers among the bacterial cells. The quorum sensing of lactic acid bacteria has been proved to play a key role in the bacteriocin synthesis.The current research progress of bacteriocin of lactic acid bacteria, including the systematic classification of the bacteriocin, the transduction mechanism of quorum sensing signals and the regulation of LAB bacteriocin synthesis, was reviewed in this article, aiming to give reference and inspiration to the development and application of bacteriocin.